journal of al-qadisiyah for pure science(quarterly)

Abstract

The experiment was conducted on 54 white rats which were divide into two main groups, 18 white rats each. The first group was given Cyclophosphamide CP ( 5 mg/kg ) of the body weight; the second was given Cyclophosphamide CP ( 5 mg/kg ) of the body weight with the water extract of licorice ( 30 mg/kg) of the body weight. Each main group was subdivided into minor groups, 6 white rats each. The control, 18 white rats, was given drinking water throughout the time of the experiment. After 7 days from the beginning of the experiment; the white rats of the first group were anatomized to find the effects of the two doses. The same procedure was followed with the third group after 21 days from the beginning of the experiment
The results have shown a significant increase ( P<0.01 ) in the chromosomal breaks in the first group treated with Cyclophosphamide CP ( 5 mg/kg ) of the body weight. This increase got higher with the passage of time as compared with the control and the second group treated with Cyclophosphamide CP ( 5 mg/kg ) of the body weight. Also, the results have shown a decrease ( P<0.01 ) in the average of chromosomal breaks in the second group treated with Cyclophosphamide CP ( 5 mg/kg ) with the water extract of licorice ( 30 mg/kg) of the body weight. The decrease got higher with the passage of time as compared with the first group. The differences were significant. The results were as follows:
1. The treatment with Cyclophosphamide CP ( 5 mg/kg ) of the body weight caused chromosomal breaks.
2. The treatment with Cyclophosphamide CP ( 5 mg/kg ) with the liquid extract of licorice ( 30 mg/kg) of the body weight cause a decrease in chromosomal breaks.