Keywords : benzothiazole


Synthesis, Characterization and Biological Activity of some new phthalimides and maleimides derivetives containing benzothiazole ring

Muhanned A. Mahmoud

journal of al-qadisiyah for pure science(quarterly), 2017, Volume 17, Issue 1, Pages 177-191

In this work, a series of new3-nitro phthalimides and bromo maleimides derivetives
containing benzothiazole ring were synthesized, the Synthesis of series of N-(substituted
benzothiazole-2-yl) 3-nitro phthalimide were performed via three steps, the first one involved
preparation of a series of substituted 2-aminobenzothiazole via reaction of different primary
aromatic amines with ammonium thiocyanate and bromine in glacial acetic acid, In the second step the
prepared amino benzothiozoles were introduced in reaction with 3- nitro phthalic anhydride producing
a series of N-(substituted benzothiazole-2-yl) 3- nitro phthalamic acid, while Fusion Method used in
preparation of a series N-(substituted benzothiazol-2-yl) bromo maleimide via Fusion The prepared
substituted 2-aminobenzothiazole with Bromo Maleic anhydride to producing a series of N-
(substituted benzothiazol-2-yl) bromo maleimide ,the synthesized compounds were identified
depending upon physical and spectral method, Microbiological activities of the prepared
compounds against four types of bacteria and one type of fungi were evaluated and the results
showed that the most tested compounds have good antibacterial and anti fungi activity .

Preparation and Identification of Some New Derivatives of 4-Bromoaniline

N. A. AL-Masoudi

journal of al-qadisiyah for pure science(quarterly), 2015, Volume 15, Issue 3, Pages 26-41

This paper is ensured synthesis of some heterocycle derivatives of 4-bromoaniline compound that
likely they are to be effective vital task was diagnosed spectrally by spectrum of IR and the spectrum
of NMR (1H & 13C), as well as using C.H.N. analysis and study of some physical properties.
Derivatives (1-5) was prepared as benzothiazole derivatives, (1) derivative was prepared by
reacting 4-bromoaniline with ammonium thiocyanate existence Br2 as a catalyst and glacial acetic acid
as medium of reaction and attended (2) & (3) derivatives by smelting of maleic and phthalic anhydride
with (1) derivative, respectively, also attended the (4) derivative by reactance (1) derivative with
potassium thiocyanate ,using the technique of microwave, (5) derivative prepared from (1) by using
microwave technique and follow the Suzuki reaction and presence of 4-cyanophenyl boronic acid,
while (7) & (8) derivatives prepared as thiazolidine derivatives from (6) derivative that was prepared
by reactance 4-bromoaniline with chloroacetylchloride, by it reacting with potassium and ammonium
thiocyanate, respectively.