Keywords : maleimides

Synthesis, Characterization and Biological Activity of some new phthalimides and maleimides derivetives containing benzothiazole ring

Muhanned A. Mahmoud

journal of al-qadisiyah for pure science(quarterly), 2017, Volume 17, Issue 1, Pages 177-191

In this work, a series of new3-nitro phthalimides and bromo maleimides derivetives
containing benzothiazole ring were synthesized, the Synthesis of series of N-(substituted
benzothiazole-2-yl) 3-nitro phthalimide were performed via three steps, the first one involved
preparation of a series of substituted 2-aminobenzothiazole via reaction of different primary
aromatic amines with ammonium thiocyanate and bromine in glacial acetic acid, In the second step the
prepared amino benzothiozoles were introduced in reaction with 3- nitro phthalic anhydride producing
a series of N-(substituted benzothiazole-2-yl) 3- nitro phthalamic acid, while Fusion Method used in
preparation of a series N-(substituted benzothiazol-2-yl) bromo maleimide via Fusion The prepared
substituted 2-aminobenzothiazole with Bromo Maleic anhydride to producing a series of N-
(substituted benzothiazol-2-yl) bromo maleimide ,the synthesized compounds were identified
depending upon physical and spectral method, Microbiological activities of the prepared
compounds against four types of bacteria and one type of fungi were evaluated and the results
showed that the most tested compounds have good antibacterial and anti fungi activity .